Alpha Lion Gains Candy Nitrosigine: Powerful Pump Pills

Clinically-studied Nitrosigine in single-ingredient pill form!

Alpha Lion is a brand that burst onto the scene and immediately started taking ground. Their motto is “Be Superhuman”, and their flagship line of products included awesome formulas like the SuperHuman Pre-Workout, SuperHuman Burn, and more.

One of their coolest ongoing projects has been the Gains Candy line. With products like Gains Candy MitoBurn and Gains Candy CaloriBurn, Alpha Lion went deconstructive. They isolated some of the industry’s hottest ingredients on the market to allow you to mix and match as you please.

Alpha Lion Gains Candy Pump & Performance: Add Pumps to Anything with Nitrosigine

One of our personal favorite Gains Candy offerings comes in the form of Nitrosigine, which we’ve covered in depth on PricePlow. Nitrosigine is a unique stabilized complex of arginine, inositol, and silicate created by Nutrition21.

Nitrosigine comes with a host of benefits like supporting healthy nitric oxide production for improved blood flow for muscle pumps and improving cognitive performance.

We’re going to dive into how Alpha Lion Gains Candy Nitrosigine works, but first, let’s check PricePlow for good Alpha Lion deals, and check out our video review of the product:

Alpha Lion Gains Candy Nitrosigine – Deals and Price Drop Alerts

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Our goal here is to increase blood flow, and thus improve muscle pumps as well as cognitive function — generally when training. To do that, we seek the support of nitric oxide (NO), which induces vasodilation,[1] a process where blood vessels relax, increasing the diameter,[2] which allows greater blood throughput. Nitrosigine is the industry-leading ingredient to make this happen:

Alpha Lion Gains Candy Pump & Performance with Nitrosigine – How It Works

This formula contains one ingredient and one ingredient only:
Alpha Lion Gains Candy Nitrosigine Ingredient

Nitrosigine, a patented complex of inositol-stabilized arginine silicate created by Nutrition21,[3] delivers a highly-bioavailable form of L-arginine, offering a more effective alternative at a lower dose for pump supplements — and that means the clinically-studied dose will fit in just 3 capsules here.

The issue with standard L-arginine, and how Nitrosigine improves it


Move over L-arginine, Nitrosigine (inositol-stabilized arginine silicate) actually makes it work as originally desired!

In the 2000s, straight L-arginine was used in early pre-workout supplements, but it was quickly discovered that it had poor oral bioavailability.[4-7] Reason being, it preferentially binds to the arginase enzyme (which breaks it down) rather than endothelial nitric oxide synthase (eNOS), the enzyme that converts it to nitric oxide (NO).[8]

So companies started adding more and more arginine to attempt to overcome this, but it leads to what researchers call the arginine paradox:[9] in order to reliably boost plasma arginine levels to the point of significant nitric oxide improvements, so much arginine is required that it leads to GI distress.[10,11]

Nitrosigine: Fast-Acting (30 minutes), Long-Lasting (6 hours)

Nutrition21 realized this, and saved the day with their patented Nitrosigine formulation,[3] known as inositol-stabilized arginine silicate or simply “ASI” in research studies. At just 1.5 grams — the dose you’ll get in 3 capsules of Gains Candy Nitrosigine, this novel nitric oxide potentiator has been shown to significantly increase serum arginine levels in as little as 30 minutes and for up to 6 hours![12,13]

Nitrosigine vs. Citrulline Malate (Mean Corrected FMD Change)

Nitrosigine vs. Citrulline Malate (Mean Corrected FMD Change).[14] Image courtesy Nutrition21

Outperforms equivalent amounts of L-citrulline

Independent research published in 2020 showed that this 1.5 gram dose was equivalent to 8 grams of citrulline malate in terms of efficacy. In that study, which was performed on very healthy adults, Nitrosigine increased flow-mediated dilation (“FMD”, a measure of arterial blood flow) by a phenomenal 31%, and did so at just 1/5th the dose![14]

To put this in perspective as a capsule-based supplement, that equivalent amount of citrulline malate would require 11 or 12 large capsules compared to the 3 used here! It’s additionally special that the participants were healthy — a more difficult demographic to meaningfully move the needle.

Nitrosigine Benefits: Beyond the Muscle

So we’ve seen Nitrosigine increase plasma arginine levels[12,13] and then increase measurements of blood flow.[14]

Nitrosigine Upper Leg Pumps

After 3 days of Nitrosigine use, upper leg pumps as measured by leg circumference were significantly increased![15]

That’s incredible if you’re looking to train, as early research showed that just four days of Nitrosigine supplementation led to greater blood flow response to exercise, ensuring optimal delivery of oxygen and nutrients to the working muscle.[15] This was measured by increased leg circumference before and after exercise and improved perceived energy (or improved feelings of energy), as measured after an intense leg extension exercise protocol.[15]

Improved Cognitive Flexibility

Additionally, Nitrosigine isn’t just for physical performance, it’s also useful for the brain. Three separate studies have highlighted how it enhances cognitive function,[16-18] specifically in terms of reducing post-workout cognitive impairment,[16] improving reaction time,[18] and increasing working memory performance.[17]

Ultimately, while most of us are using Gains Candy Pump & Performance for pumps, improving blood flow isn’t just for athletic purposes, it’s for cognitive ones as well, adding icing on the cake.

With Nitrosigine, Nutrition21 has led the way in bringing arginine back to the industry in a way that uses less active powder, enabling it to fit inside of a capsule-based supplement!


Nitrosigine can be used with other performance supplements that deliver on other benefits, such as stimulant-based pre-workouts, fat burners, or energy drinks. If you’re sticking with the Alpha Lion product line, SuperHuman Pre and SuperHuman Burn are the two popular contenders. But there are plenty of others that could use a boost in pumps, check out PricePlow’s entire pre workout supplements category page for some great deals!

Alpha Lion Gains Candy Nitrosigine Benefits

Gains Candy makes stacking blood flow and cognitive support more versatile!

Ingredient Isolation for Individuality

It makes sense: Given that Nitrosigine is more effective than other ingredients like citrulline or L-arginine — and at a lower dose — Nitrosigine was Alpha Lion’s obvious choice for a single-ingredient supplement named “Pump & Performance”.

There are of course times when we love big formulas with a dozen ingredients. That said, not everyone reacts to everything the same. For some, it’s better to isolate the best of the best in a standalone capsule form that give you exactly what you’re looking for, keeping it simple.

The Gains Candy lineup makes this process trivial. Whether you’re looking to knock off the pounds with MitoBurn and CaloriBurn or get a world-class pump with Nitrosigine, Alpha Lion has you covered.

And, let’s be honest – there are a lot of pre-workout supplements out there that could simply use the help. Gains Candy brings it, without you having to triple-scoop an inferior product to get a solid pump!

Alpha Lion Gains Candy Nitrosigine – Deals and Price Drop Alerts

Get Price Alerts

No spam, no scams.

Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

Posts are sponsored in part by the retailers and/or brands listed on this page.

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